DNA replication and repair in human cells exposed to thermal neutrons.

نویسندگان

  • M D Ford
  • M F Lavin
  • D Wilson
چکیده

Thermal neutrons/DNA replication/DNA repair The degree of inhibition of DNA replication and the level of DNA repair synthesis induced by thermal neutron irradiation was determined in human lymphoblastoid cell lines. Dose response experiments revealed that, when compared with equivalent doses of 60Co-ƒÁ-irradia tion, thermal neutrons gave rise to similar levels of inhibition of DNA replication but induced relatively low levels of DNA repair synthesis. The amount of repair synthesis after exposure of cells to thermal neutrons, was about tenfold lower than that observed after ƒÁ-radiation. Reasons for this difference are discussed in terms of the type and incidence of damage induced by thermal neutrons.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Poor Understanding of Radiation Profiles in Deep Space Causes Inaccurate Findings and Misleading Conclusions

The radiation environment in deep space, where astronauts are behind the shelter provided by the Earth’s magnetosphere, is a major health concern. Galactic cosmic rays (GCR) and solar particle events (SPE) are two basic sources of space radiation in the solar system. The health risks of exposure to high levels of space radiation can be observed either as acute and delayed effects. Zhang et al. ...

متن کامل

Studies on electron beam induced DNA damage and repair kinetics in lymphocytes by alkaline comet assay

Background: Exposure to ionizing radiation is known to induce oxidative stress followed by damage to critical biomolecules like lipids, proteins and DNA through radiolysis of cellular water. Since radiation has been widely used as an important tool in therapy of cancer, the detailed investigation regarding the DNA damage and repair kinetics would help to predict the radiation sensitivity of cel...

متن کامل

Quantitation of genome damage and transcriptional profile of DNA damage response genes in human peripheral blood mononuclear cells exposed in vitro to low doses of neutron radiation

Background: Humans are exposed to ionizing radiation from different sources that include natural, occupational, medical, accidental exposures. Evaluation of the effect of low level of neutron exposure to human cells in vitro has important implications to human health. Attempts were made to measure genome damage, transcriptional profile of DNA damage response and repair genes in peripheral blood...

متن کامل

Effects of low dose radiation on the expression of proteins related to DNA repair requiring Caveolin-1 in human mammary epithelial cells

Background: Radiotherapy is an effective and important therapeutic method for breast cancer, but at the same time it has a radiation-induced bystander effect on normal tissue around the tumor. Repair of double-strand breaks (DSBs) by normal cells can reduce the extent of damage caused by this effect. Caveolin-1 (Cav-1) is an important regulatory molecule in cell signal transduction. However, th...

متن کامل

Nickel Increases Chromosomal Abnormalities by Interfering with the Initiation of DNA Repair Pathways

Background: Nickel is a carcinogenic, heavy metal released through industrial activities and via natural resources. It is able to cause DNA damages by reducing the efficiency of DNA repair mechanisms. However, the exact time point at which it is able to interfere with these mechanisms is not yet clearly understood. Methods: To find the most nickel-vulnerable time of repair mechanisms, human de...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Journal of radiation research

دوره 23 4  شماره 

صفحات  -

تاریخ انتشار 1982